Common antibodies are directed against both cytokeratin 5 and 6. Major partner of CK5 is CK14, while CK6 pairs with CK16/17 ( Exp Cell Res 2007;313:2244, Eur J Cell Biol 2004;83:735 ) CK5 is also detected by antibodies against high molecular weight cytokeratins (such as 34 beta E12, also known as K903) and pan-CK markers (such as CK AE1 / AE3)
There was high p16 and WT1 expression in most undifferentiated carcinomas and in serous carcinomas with clear cells, suggesting that these represent variants of serous carcinoma. We have demonstrated that p16 is highly expressed in high-grade serous and undifferentiated carcinomas compared with other morphologic types of ovarian carcinoma.
Immunohistochemical Expression of p16 in Melanocytic Lesions is a research article that examines the role of p16 protein in the diagnosis and prognosis of skin tumors. It provides a comprehensive review of the literature and a meta-analysis of the accuracy and reliability of p16 immunohistochemistry. Read the full text to learn more about this useful biomarker.
Neoadjuvant chemotherapy followed by cytoreduction surgery has been used where an accurate cytologic or pathologic diagnosis is usually required before the initiation of neoadjuvant chemotherapy. However, it is difficult to make definitive diagnosis of presence of cancer cells, particularly gynecologic versus non-gynecologic origin, from those ascites specimens due to the absence of specific
Human Papillomavirus Genome and Its Integration Into the Host Cellular Genome. The HPV genome structure and the oncogenes have been discussed in this section with reference to high-risk HPV16 type (Figure 1).The HPV16 genome is a 7.9 kb long nucleotide belt, segmented into three sections: the early gene-coding region (E), the late gene-coding region (L), and the long control region (LCR), also
Expression of p16 INK4A (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC), however, p16-positivity is not limited to HPV positive tumors and therefore, not a perfect surrogate for HPV. p16 survival outcomes are b …
Discoveries related to human papillomavirus (HPV) continue to generate new implications for head and neck oncology. HPV prevalence in oropharyngeal tumors increased from 16.3 percent during the 1980s to 72.7 percent during the 2000s, with increasing recognition that HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct entity
Human papillomavirus (HPV) is a possible carcinogenetic factor in oral squamous cell carcinoma (OSCC). Previous studies have reported the prevalence of HPV in patients with OSCC. However, the association between HPV and OSCC remains controversial. The present study aimed to clarify the association between HPV infection, p16 protein expression
Positive staining is defined as "block" staining: strong nuclear and cytoplasmic expression in a continuous segment of cells (at least 10 - 20 cells); in squamous epithelium, block positivity needs to involve basal and parabasal layers
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what does p16 positive mean
